Domling laboratory

The research group "drug design" is designing and developing novel biologically active molecules for targets in therapeutic areas of unmet medical need. We are developing new "out-of-the-box" tools such as MCR chemical scaffolds to address novel biological targets or software to facilitate design of drugs. As the main tool in chemistry we use and further develop multicomponent reaction chemistry (MCR). Our designer softwareANCHOR.QUERY, for example, is helping medicinal chemist to rapidly discover novel (ant)agonists of protein interactions. We have a strong focus on cancer immunology and design small milecular weight compounds or macrocycles for the protein protein interaction  between PD1 and PD1L and enzym inhibitors for arginase.

Our state-of-the-art laboratory is well equipped to synthesize and purify medium throughput chemical libraries as well as protein expression, purification and crystallisation (Matthew Groves lab).